SLC3A2 Recombinant Protein

CD antigen CD98 is also known as 4F2 cell-surface antigen heavy chain (4F2hc), 4F2 heavy chain antigen, Solute carrier family 3 member 2 (SLC3A2), Lymphocyte activation antigen 4F2 large subunit, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family.. SLC3A2 / CD98 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. SLC3A2 / CD98 is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. CD98 involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A5 or SLC7A8, CD98 involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals.

9000-83-3

6520

P08195

AAH01061

His Tag

Recombinant Proteins

HEK293 cells

Homeostasis, Immunology, Obesity, Signal Transduction, Stem Cell

>95% as determined by SDS-PAGE.

PBS, pH7.4

Room Temp

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

47.7 kDa

This recombinant protein can be used for WB. For research use only.

Solute carrier family 3 (amino acid transporter heavy chain), member 2

Homo sapiens

Yanagida O., et al., 2001, Biochim. Biophys. Acta 1514:291-302.

Mastroberardino L., et al., 1998, Nature 395:288-291.

Okamoto Y., et al., 2002, Am. J. Physiol. 282:C196-C204.

Li S., et al., 2005, J. Biol. Chem. 280:20102-20110.

SLC3A2, CD98, 4F2, 4F2HC, 4T2HC, CD98HC, MDU1, NACAE

WB

Human