B7-H4 Recombinant Protein

• Background:

  B7H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs) . In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.

• NCBI Gene ID:

  79679

• Swiss Prot:

  P16410

• Accession Number:

  NP_078902

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Field of Research:

  Cancer, Innate Immunity

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μ l sterile water. Add 1X PBS to the desired protein concentration.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  V-set domain containing T cell activation inhibitor 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  V-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S1

• Species:

  Human

• Protein ID:

  99028881

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3