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B7-1 Recombinant Protein

CAT: 0223-92-581Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-92-581Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.
CAS Number
9000-83-3
NCBI Gene ID
12519
Swiss Prot
Q00609
Accession Number
Q00609
Tag
C-Fc tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Immunology, Innate Immunity
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
50.8 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
CD80 antigen
NCBI Organism
Mus musculus
Other Product Names
T-lymphocyte activation antigen CD80, Activation B7-1 antigen, B7, CD80
Species
Mouse
Physical Properties
Lyophilized

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