B7-H3 Recombinant Protein

• Background:

  CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.

• NCBI Gene ID:

  80381

• Swiss Prot:

  Q5ZPR3

• Accession Number:

  Q5ZPR3

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cancer, Cell Cycle, Immunology

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  47.3 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  CD276 molecule

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CD276, B7H34Ig-B7-H3, B7-H3, B7 homolog 3, CD276 antigen, CD276 molecule, Costimulatory molecule

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3