B7-1 Recombinant Protein

• Background:

  Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.

• NCBI Gene ID:

  941

• Swiss Prot:

  P33681

• Accession Number:

  P33681

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cancer, Cell Cycle, Chemokines & Cytokines, Immunology, Innate Immunity, Signal Transduction

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  24.7 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  CD80 molecule

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CD80, Activation B7-1 antigen, B7, BB1, CD28LG1, CD28LGB7-1 antigen, T-lymphocyte activation antigen CD80

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3