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ATG7 Recombinant Protein

CAT: 0223-95-122Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-95-122Size:0.05 mg
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Background
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) . This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3) . Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog (4) . In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles (5) . It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death (6) .
CAS Number
9000-83-3
NCBI Gene ID
74244
Swiss Prot
Q9D906
Accession Number
AAH58597
Tag
Fusion Partner:
Type
Recombinant Proteins
Source
E. coli
Field of Research
Autophagy
Purity
~95%
Buffer
1X PBS containing 10% glycerol
Shipping Conditions
Dry Ice
Storage Conditions
Store in working aliquots at -70˚ C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Calculated Molecular Weight
30 kDa (Calculated)
Applications Notes
This recombinant protein can be used for WB and ELISA. For research use only.
NCBI Official Name
Autophagy related 7
NCBI Organism
Mus musculus
Background Reference 01
Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene . 2004; 23:2891-906.
Background Reference 02
Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993; 14:2501-5.
Background Reference 03
Kamada Y, Funakoshi T, Shintani T, et al. Tor-mediated induction of autophagy via Apg1 protein kinase complex. J. Cell. Biol. 2000; 150:1507-13.
Background Reference 04
Mizushima N, Noda T, Yoshimori T, et al. A protein conjugation system essential for autophagy. Nature 1998; 395:395-8.
Other Product Names
ATG7 Recombinant Protein: Agp7, Apg7l, Atg7l, Gm21553, 1810013K23Rik
Tested Applications
ELISA, WB
Species
Mouse
Protein ID
37589293
Physical Properties
Liquid

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