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ATG5 Recombinant Protein

CAT: 0223-95-121Size: 0.05 mgDry Ice: YesHazardous: No
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CAT#:0223-95-121Size:0.05 mg
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Background
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) . This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3) . ATG5, another member of the autophagy protein family, forms a conjugate with ATG12; this conjugate has a ubiquitin-protein ligase (E3) -like activity for protein lipidation in autophagy (4) . This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells (5) .
CAS Number
9000-83-3
NCBI Gene ID
9474
Swiss Prot
A9UGY9
Accession Number
AAH02166
Tag
Fusion Partner:
Type
Recombinant Proteins
Source
E. coli
Field of Research
Autophagy, Homeostasis, Innate Immunity, Signal Transduction
Purity
~95%
Buffer
1X PBS containing 10% glycerol
Shipping Conditions
Dry Ice
Storage Conditions
Store in working aliquots at -70˚ C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Calculated Molecular Weight
34 kDa (Calculated)
Applications Notes
This recombinant protein can be used for WB and ELISA. For research use only.
NCBI Official Name
ATG5 autophagy related 5 homolog (S. cerevisiae)
NCBI Organism
Homo sapiens
Background Reference 01
Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene . 2004; 23:2891-906.
Background Reference 02
Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993; 14:2501-5.
Background Reference 03
Kamada Y, Funakoshi T, Shintani T, et al. Tor-mediated induction of autophagy via Apg1 protein kinase complex. J. Cell. Biol. 2000; 150:1507-13.
Background Reference 04
Hanada T, Noda NN, Satomi Y, et al. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J. Biol. Chem. 2007; 282:37298-302.
Other Product Names
ATG5 Antibody: ASP, APG5, APG5L, hAPG5, APG5-LIKE
Tested Applications
ELISA, WB
Species
Mouse
Protein ID
10285391
Physical Properties
Liquid

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