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ANGPTL4 Recombinant Protein

CAT: 0223-90-075Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0223-90-075Size:50 µg
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Background
ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced) . Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD) . Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
CAS Number
9000-83-3
NCBI Gene ID
57875
Swiss Prot
Q9Y5C1
Accession Number
Q9Z1P8
Tag
DDDDK Tag
Type
Recombinant Proteins
Source
COS-7 cells
Field of Research
Cancer, Obesity
Concentration
1mg/ml
Buffer
0.2um-filtered solution in PBS.
Shipping Conditions
Blue Ice
Storage Conditions
Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Angiopoietin-like 4
NCBI Organism
Mus musculus
Other Product Names
Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein
Species
Mouse
Protein ID
25008127
Physical Properties
Liquid

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