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ANGPTL4 Antibody

CAT: 0223-63-837Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-837Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ANGPTL4 is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This protein is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes.
NCBI Gene ID
51129
Swiss Prot
Q9BY76
Accession Number
Q9BY76
Host
Rabbit
Reactivity
Human
Immunogen
This ANGPTL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the Central region of human ANGPTL4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Symbol
ANGPTL4
NCBI Official Name
Angiopoietin-related protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Maxwell, T.J., et.al., IntMol Sci 11 (1), 370-385 (2010)
Background Reference 02
Legry, V., et.al, J. Clin. Endocrinol. Metab. 94 (12), 5070-5077 (2009)
Background Reference 03
Sonnenburg, W.K., et.al, J. Lipid Res. 50 (12), 2421-2429 (2009)
Other Product Names
Angiopoietin-related protein 4, Angiopoietin-like protein 4, Hepatic fibrinogen/angiopoietin-related protein, HFARP, ANGPTL4, ARP4, HFARP, PGAR
Tested Applications
WB, IHC-P, Flow
Protein ID
25008123
Physical Properties
Liquid

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