ANGPTL4 fibrinogen-like domain Recombinant Protein

• Background:

  ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced) . Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD) . Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.

• NCBI Gene ID:

  51129

• Swiss Prot:

  P31431

• Accession Number:

  Q9BY76

• Tag:

  DDDDK Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Concentration:

  0.5 mg/ml

• Buffer:

  0.2um-filtered solution in PBS.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Angiopoietin like 4

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein

• Species:

  Human

• Protein ID:

  25008123

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3