FAK-IN-14

• UNSPSC Description:

  FAK-IN-14 (compound 8d) is a focal adhesion kinase(FAK) inhibitor with an IC50 value of 0.2438 nM. FAK-IN-14 induces U87-MG cell early apoptosis and arrest the cell at the G2/M phase[1].

• Target Antigen:

  FAK

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fak-in-14.html

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  CN(CC1)CCN1C(C=C2)=CC=C2NC3=NC=C(Br)C(NC4=C(C(NC)=O)SC=C4)=N3

• Molecular Weight:

  502.43

• References & Citations:

  [1]Zhiwu Long, et al. Design, synthesis and biological evaluation of 4-arylamino-pyrimidine derivatives as focal adhesion kinase inhibitors. Bioorg Chem. 2023.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2766666-22-0