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FAK-IN-8

CAT: 0804-HY-148110Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-148110Size:1 Each
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Description
FAK-IN-8 (compound 5h) is a FAK inhibitor (IC50=5.32 μM) . FAK-IN-8 has good anti-proliferative activity and can be used in cancer research[1].
CAS Number
1374959-91-7
UNSPSC
12352005
Target
FAK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fak-in-8.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NN=C(C2=CC=C(Cl)C=C2)S1)C3=CC(Cl)=CC=C3O
Molecular Formula
C15H9Cl2N3O2S
Molecular Weight
366.22
References & Citations
[1]Yang XH, et al. Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents. Bioorg Med Chem. 2012 May 1;20 (9) :2789-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Fak-IN-8
CAS Number1374959-91-7
PubChem CID60150400
IUPAC Name5-chloro-N-[5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-hydroxybenzamide
Molecular FormulaC15H9Cl2N3O2S
Molecular Weight366.2
XLogP4.6
Topological Polar Surface Area103
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity424
SMILES
C1=CC(=CC=C1C2=NN=C(S2)NC(=O)C3=C(C=CC(=C3)Cl)O)Cl
InChI
InChI=1S/C15H9Cl2N3O2S/c16-9-3-1-8(2-4-9)14-19-20-15(23-14)18-13(22)11-7-10(17)5-6-12(11)21/h1-7,21H,(H,18,20,22)
InChIKey
GHUOPRQFFSMJCG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Fak-IN-8
CAS: 1374959-91-7
CID: 60150400
Formula: C15H9Cl2N3O2S
MW: 366.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight366.2
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass364.9792531
Monoisotopic Mass364.9792531
Topological Polar Surface Area103 Ų
Heavy Atom Count23
Formal Charge0
Complexity424
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
GTR19187138-01FAK-IN-8
sc-271195FAK (B-8)
sc-271195 HRPFAK (B-8) HRP
sc-271195 PFAK (B-8) P
sc-271195 FITCFAK (B-8) FITC
sc-271195 ACFAK (B-8) AC
sc-271195 PEFAK (B-8) PE
sc-271195 AF647FAK (B-8) Alexa Fluor® 647
sc-271195 AF546FAK (B-8) Alexa Fluor® 546
sc-271195 AF790FAK (B-8) Alexa Fluor® 790

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