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FAK-IN-14

CAT: 1410-M37125-01Size: 1 EachDry Ice: NoHazardous: No
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CAT#:1410-M37125-01Size:1 Each
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Description
FAK-IN-14 is a highly effective focal adhesion kinase (FAK) inhibitor that induces apoptosis and cell cycle arrest. FAK-IN-14 has weak inhibitory effects on Akt, c-kit, MEK1/2 and mTOR, but has significant inhibitory effects on FAK, FGFR1 and Pyk2.
CAS Number
2766666-22-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
502.43
Molecular Formula
C21H24BrN7OS
Notes
Research use only, not for human use.
Receptor
FAK | FGFR | PYK2 | mTOR | MEK | Akt | c-Kit

Chemical Information

Fak-IN-14
CAS Number2766666-22-0
PubChem CID169450787
IUPAC Name3-[[5-bromo-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]-N-methylthiophene-2-carboxamide
Molecular FormulaC21H24BrN7OS
Molecular Weight502.4
XLogP4.4
Topological Polar Surface Area114
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count31
Formal Charge0
Complexity586
SMILES
CNC(=O)C1=C(C=CS1)NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)N4CCN(CC4)C
InChI
InChI=1S/C21H24BrN7OS/c1-23-20(30)18-17(7-12-31-18)26-19-16(22)13-24-21(27-19)25-14-3-5-15(6-4-14)29-10-8-28(2)9-11-29/h3-7,12-13H,8-11H2,1-2H3,(H,23,30)(H2,24,25,26,27)
InChIKey
SDQZXGWKKZXIEP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Fak-IN-14
CAS: 2766666-22-0
CID: 169450787
Formula: C21H24BrN7OS
MW: 502.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight502.4
XLogP34.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass501.09464
Monoisotopic Mass501.09464
Topological Polar Surface Area114 Ų
Heavy Atom Count31
Formal Charge0
Complexity586
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
GTR19235810-01FAK-IN-14
TBI2547-50MGFAK inhibitor 14, FAK inhibitor
TRC-F101073-500MGFAK Inhibitor 14
315588-01FAK

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