FAK-IN-2

FAK-IN-2

• CAS Number: 2872588-02-6
• UNSPSC Description: FAK-IN-2 is a potent and orally active focal adhesion kinase (FAK) inhibitor, with anticancer activity (FAK IC50= 35 nM). FAK-IN-2 covalently inhibits the autophosphorylation of FAK in a dose-dependent manner, and inhibits the clone formation and migration of tumor cells, inducing apoptosis[1].
• Target Antigen: Apoptosis; FAK
• Type: Reference compound
• Related Pathways: Apoptosis;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/fak-in-2.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: C=CC(N[C@@H](C(N1CCN(CC1)C2=CC=C(C=C2)NC3=NC(NC4=C(C=CC=C4)C(NC)=O)=C(C=N3)Cl)=O)C)=O
• Molecular Weight: 563.05
• References & Citations: [1]Chen T, et al. Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase. Bioorg Med Chem Lett. 2021;54:128433.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported