FAK-IN-2
CAT:
804-HY-144448-01
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
FAK-IN-2
- CAS Number: 2872588-02-6
- UNSPSC Description: FAK-IN-2 is a potent and orally active focal adhesion kinase (FAK) inhibitor, with anticancer activity (FAK IC50= 35 nM). FAK-IN-2 covalently inhibits the autophosphorylation of FAK in a dose-dependent manner, and inhibits the clone formation and migration of tumor cells, inducing apoptosis[1].
- Target Antigen: Apoptosis; FAK
- Type: Reference compound
- Related Pathways: Apoptosis;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/fak-in-2.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: C=CC(N[C@@H](C(N1CCN(CC1)C2=CC=C(C=C2)NC3=NC(NC4=C(C=CC=C4)C(NC)=O)=C(C=N3)Cl)=O)C)=O
- Molecular Weight: 563.05
- References & Citations: [1]Chen T, et al. Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase. Bioorg Med Chem Lett. 2021;54:128433.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported