FAK-IN-20

FAK-IN-20

• CAS Number: 3004967-41-0
• UNSPSC Description: FAK-IN-20 (Compound 7b) is an inhibitor of FAK with an IC50 value of 0.27 nM. FAK-IN-20 exhibits anticancer activity. FAK-IN-20 can arrest the cell cycle in the G2/M phase and induce cell apoptosis by generating ROS[1].
• Target Antigen: Apoptosis; FAK
• Type: Reference compound
• Related Pathways: Apoptosis;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/fak-in-20.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC)C1=CC=CC=C1NC2=C(Cl)C=NC(NC3=C(OC)C=C(NS(CCN4C[C@@H](C)O[C@@H](C)C4)(=O)=O)C=C3)=N2
• Molecular Weight: 604.12
• References & Citations: [1]Li R, et al. Discovery of 2,4-diarylaminopyrimidine derivatives bearing sulfonamide moiety as novel FAK inhibitors. Bioorg Chem. 2024;144:107134.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported