MD01-67

• Description :

  MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with Ki of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models[1].

• CAS Number :

  [2468971-42-6]

• UNSPSC :

  12352209

• Target :

  Neurotensin Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/md01-67.html

• Smiles :

  OC(C=C1)=CC=C1C[C@H](NC([C@H]2NC([C@@H](NC([C@@H](NC([C@H](C/C=C/C2)N)=O)CCCCN)=O)CCCCN)=O)=O)C(N[C@H](C(O)=O)CC3CCCC3)=O

• Molecular Formula :

  C37H58N8O8

• Molecular Weight :

  742.91

• References & Citations :

  [1]Desgagné M, et al., Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid-Free Analgesics. Angew Chem Int Ed Engl. 2024 Nov 18;63 (47) :e202405941.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported