Ac-IETD-AFC

Ac-IETD-AFC

• CAS Number: 211990-57-7
• UNSPSC Description: Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B[1].
• Target Antigen: Caspase
• Type: Dye Reagents
• Related Pathways: Apoptosis
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/ac-ietd-afc.html
• Purity: 99.91
• Solubility: DMSO : 125 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic)
• Smiles: FC(F)(C(C(C(O1)=C2)=CC=C2NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)[C@@H](C)CC)=O)=O)=O)=O)=CC1=O)F
• Molecular Weight: 729.65
• References & Citations: [1][1]Kazimierz Weglarczyk, et al. Caspase-8 activation precedes alterations of mitochondrial membrane potential during monocyte apoptosis induced by phagocytosis and killing of Staphylococcus aureus. Infect Immun. 2004 May;72(5):2590-7. |[2]Przemysław Reszka, et al. Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substrates. ChemMedChem. 2010 Jan;5(1):103-17.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported