INF 195

CAT: 0804-HY-164304-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-164304-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC50 value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury[1].
CAS Number
[1211379-56-4]
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR) ; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/inf-195.html
Purity
99.58
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1CN(C(CCC2=CC=CC=C2Cl)=O)CCC1)OCC
Molecular Formula
C17H22ClNO3
Molecular Weight
323.81
References & Citations
[1]Gastaldi S, et al. Novel NLRP3 inhibitor INF195: Low doses provide effective protection against myocardial ischemia/reperfusion injury. Vascul Pharmacol. 2024 Jun 17;156:107397.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; NLRP3

Related Products

CatalogName
HY-150616-01SJPYT-195
HY-135484-01NDSB-195
HY-123428MSK-195
HY-19195TO-195 (hydrochlorid)
HY-163364DS-22-inf-021
HY-170947Antitumor agent-195
HY-158005Anticancer agent 195
HY-D0702Solvent red 195
HY-162329Antibacterial agent 195
HY-P1842MAGE-A3 (195-203)

Alternative Products

CatalogName
MBS1289292-01Recombinant Ralstonia solanacearum 30S ribosomal protein S18 (rpsR)
MBS1289290-01Recombinant Moorella thermoacetica Probable chemoreceptor glutamine deamidase CheD (cheD)
MBS1289285-01Recombinant Bacillus anthracis Transcriptional regulator MntR (mntR)
MBS1289284-01Recombinant Rhizobium leguminosarum bv. viciae N-acyl homoserine lactonase AttM (attM)
MBS1289265-01Recombinant Thiobacillus denitrificans 30S ribosomal protein S11 (rpsK)
MBS1289259-01Recombinant Methanosarcina acetivorans 3-isopropylmalate dehydratase large subunit 1 (leuC1)
MBS1289252-01Recombinant Sclerotinia sclerotiorum Endo-polygalacturonase (PG1)
MBS1289238-01Recombinant Bovine Hepatoma-derived growth factor (HDGF)
MBS1289236-01Recombinant Arabidopsis thaliana Probable serine protease EDA2 (EDA2)
MBS1286472-01Recombinant Yersinia pseudotuberculosis 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB)

Popular Products