INF 195

• Description :

  INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC50 value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury[1].

• CAS Number :

  [1211379-56-4]

• UNSPSC :

  12352005

• Target :

  Interleukin Related; NOD-like Receptor (NLR) ; Pyroptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/inf-195.html

• Purity :

  99.58

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  O=C(C1CN(C(CCC2=CC=CC=C2Cl)=O)CCC1)OCC

• Molecular Formula :

  C17H22ClNO3

• Molecular Weight :

  323.81

• References & Citations :

  [1]Gastaldi S, et al. Novel NLRP3 inhibitor INF195: Low doses provide effective protection against myocardial ischemia/reperfusion injury. Vascul Pharmacol. 2024 Jun 17;156:107397.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IL-1; NLRP3