MK-8719

MK-8719

• CAS Number: 1382799-40-7
• UNSPSC Description: MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1].
• Target Antigen: OGA
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/mk-8719.html
• Purity: 99.55
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 6.67 mg/mL
• Smiles: O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1C(F)F
• Molecular Weight: 268.285
• References & Citations: [1]Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 1