MK-2295

MK-2295

• CAS Number: 573678-04-3
• UNSPSC Description: MK-2295 (NGD-8243) is a TRPV1 antagonist. MK-2295 is an analgesic agent, and can be used for research of pain[1][2].
• Target Antigen: TRP Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mk-2295.html
• Solubility: 10 mM in DMSO
• Smiles: C1=CC(=C(N=C1)C2=CC3=C(C=C2)C(=NC=N3)NC4=CC=C(C=C4)C(F)(F)F)C(F)(F)F
• Molecular Weight: 434.34
• References & Citations: [1]Gunthorpe MJ, et al. Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway. Drug Discov Today. 2009 Jan;14(1-2):56-67.|[2]Arthur Gomtsyan, et al. Chapter 8 - Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents. TRP Channels as Therapeutic Targets. From Basic Science to Clinical Use. 2015, Pages 129-144.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 2