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RAGE antagonist peptide (TFA)

CAT: 0804-HY-P2268A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2268A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities[1][2].
UNSPSC
12352209
Target
Amyloid-β
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rage-antagonist-peptide-tfa.html
Purity
99.41
Solubility
DMSO : ≥ 50 mg/mL|H2O : 14.29 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)NC(C)=O.O=C(O)C(F)(F)F
Molecular Formula
C59H102F3N13O19S
Molecular Weight
1386.58
References & Citations
[1]Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18 (16) :4356-64.|[2]Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173 (17) :2600-13.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Int J Biol Sci. 2024 Jan 1;20 (2) :784-800.|Adv Biol (Weinh) . 2025 Jun 4:e00761.|Cell Commun Signal. 2023 May 1;21 (1) :86.|J Immunol. 2025 Jun 28:vkaf125.

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