AM-8123

• Description :

  AM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease[1].

• UNSPSC :

  12352005

• Target :

  Apelin Receptor (APJ)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/am-8123.html

• Purity :

  99.89

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C)O[C@@H](C1=NC=C(C)C=N1)[C@H](C)S(NC2=NN=C(C3=CN=CC(C)=C3)N2C4=C(C=CC=C4OC)OC)(=O)=O

• Molecular Formula :

  C27H33N7O5S

• Molecular Weight :

  567.66

• References & Citations :

  [1]Ason B, et al. Cardiovascular response to small-molecule APJ activation. JCI Insight. 2020;5 (8) :e132898. Published 2020 Apr 23. doi:10.1172/jci.insight.132898

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2049973-02-4]