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AM-8123

CAT: 0804-HY-139486-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139486-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease[1].
CAS Number
2049973-02-4
UNSPSC
12352005
Target
Apelin Receptor (APJ)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/am-8123.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)O[C@@H](C1=NC=C(C)C=N1)[C@H](C)S(NC2=NN=C(C3=CN=CC(C)=C3)N2C4=C(C=CC=C4OC)OC)(=O)=O
Molecular Formula
C27H33N7O5S
Molecular Weight
567.66
References & Citations
[1]Ason B, et al. Cardiovascular response to small-molecule APJ activation. JCI Insight. 2020;5 (8) :e132898. Published 2020 Apr 23. doi:10.1172/jci.insight.132898
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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