Products for Research Use Only
RegisterLogin

ORG 30276

CAT: 0804-HY-P2446Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P2446Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ORG 30276 (APTAA-LHRH) is a potent GnRH antagonist that effectively reduces serum LH and FSH levels in male rats. ORG 30276 significantly decreases unoccupied pituitary GnRH receptors, leading to suppressed gonadotropin secretion. ORG 30276 treatment results in a considerable reduction in mRNA levels of gonadotropin beta-subunits in the pituitary gland. ORG 30276's effects on gonadotropin dynamics can be selectively reversed by the replacement of specific sex steroids, with androgens being particularly effective for the FSH beta-subunit mRNA levels.
CAS Number
83539-08-6
Product Name Alternative
APTAA-LHRH
UNSPSC
12352209
Target
GnRH Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/org-30276.html
Smiles
ClC(C=C1)=CC=C1C[C@@H](NC([C@H](NC(C)=O)CC2=CC=C(C=C2)Cl)=O)C(N[C@@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(N[C@H](C)C(O)=O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)CC5=CNC6=CC=CC=C56)=O
Molecular Formula
C69H91Cl2N17O14
Molecular Weight
1453.47
References & Citations
[1]Gonadotropin gene expression and secretion in gonadotropin-releasing hormone antagonist-treated male rats: effect of sex steroid replacement
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P2113ORG-2766
HY-118152-01Org-12962
HY-19410ORG-25435
HY-120029Org-9935
HY-105911Org 6582
HY-106965Org 21465
HY-P0037Org-30850
HY-107527AOrg 25543
HY-W223348Org-9768
HY-105472ORG 31433

Popular Products