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AZ-PFKFB3-67

CAT: 0804-HY-101972-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101972-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1, respectively. AZ-PFKFB3-67 reduces MCL-1. AZ-PFKFB3-67 has neuroprotective activity[1][2][3].
CAS Number
1704741-11-6
UNSPSC
12352005
Target
Bcl-2 Family; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/az-pfkfb3-67.html
Purity
97.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1NCCC1)NC2=CC=C(OC3=CC4=C(N(CC5=C(C)ON=C5C)C=C4C#N)C=C3)C=C2
Molecular Formula
C26H25N5O3
Molecular Weight
455.51
References & Citations
[1]Boyd S, et al. Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem. 2015;58 (8) :3611-3625.|[2]Sneyers F, et al. Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells. Cell Death Dis. 2023 Sep 8;14 (9) :600. |[3]Madai S, et al. Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism. Theranostics. 2024 Apr 29;14 (7) :2856-2880.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS5776457AZ-PFKFB3-67
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A17214-10AZ-PFKFB3-67 10mg
A17214-100AZ-PFKFB3-67 100mg
A17214-25AZ-PFKFB3-67 25mg
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