Proguanil

• Description:

  Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784) . Proguanil is a dihydrofolate reductase (DHFR) inhibitor[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Antifolate; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Proguanil.html

• Purity:

  99.84

• Solubility:

  DMSO : ≥ 130 mg/mL

• Smiles:

  N=C(NC1=CC=C(Cl)C=C1)NC(NC(C)C)=N

• Molecular Formula:

  C11H16ClN5

• Molecular Weight:

  253.73

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12.|[2]Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43 (6) :1334-9.|[3]Lochner M, et al. The antimalarial drug proguanil is an antagonist at 5-HT3 receptors. J Pharmacol Exp Ther. 2014 Dec;351 (3) :674-84.|[4]Stephen AO, et al. Prolonged administration of proguanil induces reproductive toxicity in male rats. J Toxicol Sci. 2011 Oct;36 (5) :587-99.|[5]Iguchi A, et al. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol. 2013 Nov 8;197 (3-4) :527-33.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Plasmodium

• CAS Number:

  [500-92-5]