Proguanil

CAT: 0804-HY-B0806-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0806-01Size:5 mg
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Description
Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784) . Proguanil is a dihydrofolate reductase (DHFR) inhibitor[1][2].
CAS Number
[500-92-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antifolate; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Proguanil.html
Purity
99.84
Solubility
DMSO : ≥ 130 mg/mL
Smiles
N=C(NC1=CC=C(Cl)C=C1)NC(NC(C)C)=N
Molecular Formula
C11H16ClN5
Molecular Weight
253.73
Precautions
H302, H315, H319, H335
References & Citations
[1]Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12.|[2]Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43 (6) :1334-9.|[3]Lochner M, et al. The antimalarial drug proguanil is an antagonist at 5-HT3 receptors. J Pharmacol Exp Ther. 2014 Dec;351 (3) :674-84.|[4]Stephen AO, et al. Prolonged administration of proguanil induces reproductive toxicity in male rats. J Toxicol Sci. 2011 Oct;36 (5) :587-99.|[5]Iguchi A, et al. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol. 2013 Nov 8;197 (3-4) :527-33.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Plasmodium

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