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Proguanil (Standard)

CAT: 0804-HY-B0806R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0806R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proguanil (Standard) is the analytical standard of Proguanil. This product is intended for research and analytical applications. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil. Proguanil is a dihydrofolate reductase (DHFR) inhibitor[1][2].
CAS Number
500-92-5
UNSPSC
12352005
Target
Antifolate; Parasite; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/proguanil-standard.html
Smiles
N=C(NC1=CC=C(Cl)C=C1)NC(NC(C)C)=N
Molecular Formula
C11H16ClN5
Molecular Weight
253.73
References & Citations
[1]Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12.|[2]Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43 (6) :1334-9.|[3]Lochner M, et al. The antimalarial drug proguanil is an antagonist at 5-HT3 receptors. J Pharmacol Exp Ther. 2014 Dec;351 (3) :674-84.|[4]Stephen AO, et al. Prolonged administration of proguanil induces reproductive toxicity in male rats. J Toxicol Sci. 2011 Oct;36 (5) :587-99.|[5]Iguchi A, et al. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol. 2013 Nov 8;197 (3-4) :527-33.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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