Proguanil (Standard)

Proguanil (Standard)

• CAS Number: 500-92-5
• UNSPSC Description: Proguanil (Standard) is the analytical standard of Proguanil. This product is intended for research and analytical applications. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor[1][2].
• Target Antigen: Antifolate; Parasite
• Type: Reference Standards
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/proguanil-standard.html
• Smiles: N=C(NC1=CC=C(Cl)C=C1)NC(NC(C)C)=N
• Molecular Weight: 253.73
• References & Citations: [1]Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12.|[2]Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43(6):1334-9.|[3]Lochner M, et al. The antimalarial drug proguanil is an antagonist at 5-HT3 receptors. J Pharmacol Exp Ther. 2014 Dec;351(3):674-84.|[4]Stephen AO, et al. Prolonged administration of proguanil induces reproductive toxicity in male rats. J Toxicol Sci. 2011 Oct;36(5):587-99.|[5]Iguchi A, et al. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol. 2013 Nov 8;197(3-4):527-33.
• Shipping Conditions: Room temperature