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THS-044

CAT: 0804-HY-19621-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19621-01Size:5 mg
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Description
THS-044 is a modulator of the formation of the HIF2α/ARNT heterodimer. THS-044 binding stabilizes the HIF2α PAS-B folded state (KD = 2 μM), for regulating HIF2 activity in endogenous and pathological settings, and does not bind to HIF1α or ARNT PAS-B. THS-044 increases the KD of the heterodimer formed by HIF2α PAS-B and ARNT PAS-B from 120 μM to 400 μM. THS-044 can be used for the study of diseases related to hypoxia[1][2].
CAS Number
[62054-67-5]
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/THS-044.html
Purity
99.67
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(C1=CC=C(NN2CCOCC2)C([N+]([O-])=O)=C1)(F)F
Molecular Formula
C11H12F3N3O3
Molecular Weight
291.23
References & Citations
[1]Scheuermann TH, et al. Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci U S A. 2009 Jan 13;106 (2) :450-455.|[2]Nordgren, Ida Karin, and Ali Tavassoli. Targeting tumour angiogenesis with small molecule inhibitors of hypoxia inducible factor. Chemical Society Reviews 40.8 (2011) : 4307-4317.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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