NP-G2-044

• Description :

  NP-G2-044 is a potent, orally active fascin inhibitor, with an IC50 of ~2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response[1][2].

• CAS Number :

  [1807454-59-6]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  β-catenin

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/np-g2-044.html

• Purity :

  99.75

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(C)OC=C1)NC2=NN(CC3=CC=C(C(F)(F)F)C=C3)C4=C2C=CC=C4

• Molecular Formula :

  C21H16F3N3O2

• Molecular Weight :

  399.37

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Han S, et al. Improving fascin inhibitors to block tumor cell migration and metastasis. Mol Oncol. 2016;10 (7) :966-980.|[2]Vincent Chung, et al. Abstract C053: NP-G2-044, a novel fascin inhibitor, blocks tumor metastasis and increases antitumor immune response.|[3]Fascin Inhibitor NP-G2-044.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2