TAK 044

• Description :

  TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction, acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage[1].

• UNSPSC :

  12352209

• Target :

  Endothelin Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/tak-044.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@@H](NC([C@H](C1=CC=CS1)NC([C@@H](NC([C@@H](NC([C@H](NC2=O)CC(O[Na])=O)=O)CC(N3CCN(C4=CC=CC=C4)CC3)=O)=O)CC(O[Na])=O)=O)=O)CC(C)C)N[C@@H]2CC5=CNC6=CC=CC=C56

• Molecular Formula :

  C45H51N9Na2O11S

• Molecular Weight :

  971.98

• References & Citations :

  [1]Toshifumi Watanabe, et al. TAK-044: An Endothelin Receptor Antagonist. , 14 (1), 36–46.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  Phase 2

• CAS Number :

  [157380-72-8]