TAK 044

• Description:

  TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction, acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage[1].

• UNSPSC:

  12352209

• Target:

  Endothelin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/tak-044.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C ([C@@H] (NC ([C@H] (C1=CC=CS1) NC ([C@@H] (NC ([C@@H] (NC ([C@H] (NC2=O) CC (O[Na]) =O) =O) CC (N3CCN (C4=CC=CC=C4) CC3) =O) =O) CC (O[Na]) =O) =O) =O) CC (C) C) N[C@@H]2CC5=CNC6=CC=CC=C56

• Molecular Formula:

  C45H51N9Na2O11S

• Molecular Weight:

  971.98

• References & Citations:

  [1]Toshifumi Watanabe, et al. TAK-044: An Endothelin Receptor Antagonist. , 14 (1), 36–46.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  Phase 2

• CAS Number:

  157380-72-8