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MJ04

CAT: 0804-HY-161618-05Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161618-05Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides ‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg).
CAS Number
2099014-23-8
UNSPSC
12352005
Target
EGFR; GSK-3; IGF-1R; JAK; PI3K
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mj04.html
Purity
98.08
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC=C(C2=CN=C(NC=C3C4=NC(NC5CC5)=NC=C4)C3=C2)C=C1
Molecular Formula
C20H16FN5
Molecular Weight
345.37
References & Citations
[1]Hossain MM, et al., Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter. J Transl Med. 2024 Apr 18;22 (1) :370.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; GSK-3β; JAK1; JAK2; JAK3; PI3Kγ

Chemical Information

N-cyclopropyl-4-[5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
CAS Number2099014-23-8
PubChem CID129206886
IUPAC NameN-cyclopropyl-4-[5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Molecular FormulaC20H16FN5
Molecular Weight345.4
XLogP3.9
Topological Polar Surface Area66.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity479
SMILES
C1CC1NC2=NC=CC(=N2)C3=CNC4=C3C=C(C=N4)C5=CC=C(C=C5)F
InChI
InChI=1S/C20H16FN5/c21-14-3-1-12(2-4-14)13-9-16-17(11-24-19(16)23-10-13)18-7-8-22-20(26-18)25-15-5-6-15/h1-4,7-11,15H,5-6H2,(H,23,24)(H,22,25,26)
InChIKey
IWEFQYFFHNADPN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-cyclopropyl-4-[5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
CAS: 2099014-23-8
CID: 129206886
Formula: C20H16FN5
MW: 345.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.4
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass345.13897369
Monoisotopic Mass345.13897369
Topological Polar Surface Area66.5 Ų
Heavy Atom Count26
Formal Charge0
Complexity479
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
GTR19234243-01MJ04

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