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MJ04

CAT: 0931-T87974-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T87974-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2099014-23-8
Target
EGFR, JAK, PI3K, GSK-3, IGF-1R
Related Pathways
PI3K/Akt/mTOR signaling, Angiogenesis, Stem Cells, JAK/STAT signaling, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors
Bioactivity
MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg) .
Smiles
FC=1C=CC(=CC1)C2=CN=C3NC=C(C=4N=C(N=CC4)NC5CC5)C3=C2
Molecular Formula
C20H16FN5
Molecular Weight
345.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-161618-01MJ04

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