Products for Research Use Only
RegisterLogin

MJ04

CAT: 0013-GTR19234243-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19234243-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MJ04 is a potent and selective JAK3 inhibitor (IC50=2.03 nM) that impedes T cell differentiation and reduces LPS-induced cytokine production in macrophages. Demonstrating favorable pharmacokinetics, it has shown efficacy in promoting hair growth in a murine alopecia model with a high safety profile (LD50>2 g/kg) .
CAS Number
2099014-23-8
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
FC=1C=CC (=CC1) C2=CN=C3NC=C (C=4N=C (N=CC4) NC5CC5) C3=C2
Molecular Formula
C20H16FN5
Molecular Weight
345.37
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-cyclopropyl-4-[5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
CAS Number2099014-23-8
PubChem CID129206886
IUPAC NameN-cyclopropyl-4-[5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Molecular FormulaC20H16FN5
Molecular Weight345.4
XLogP3.9
Topological Polar Surface Area66.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity479
SMILES
C1CC1NC2=NC=CC(=N2)C3=CNC4=C3C=C(C=N4)C5=CC=C(C=C5)F
InChI
InChI=1S/C20H16FN5/c21-14-3-1-12(2-4-14)13-9-16-17(11-24-19(16)23-10-13)18-7-8-22-20(26-18)25-15-5-6-15/h1-4,7-11,15H,5-6H2,(H,23,24)(H,22,25,26)
InChIKey
IWEFQYFFHNADPN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-cyclopropyl-4-[5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
CAS: 2099014-23-8
CID: 129206886
Formula: C20H16FN5
MW: 345.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.4
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass345.13897369
Monoisotopic Mass345.13897369
Topological Polar Surface Area66.5 Ų
Heavy Atom Count26
Formal Charge0
Complexity479
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-161618-01MJ04

Popular Products