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MJ04

CAT: 0931-T87974-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T87974-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2099014-23-8
Target
EGFR, JAK, PI3K, GSK-3, IGF-1R
Related Pathways
PI3K/Akt/mTOR signaling, Angiogenesis, Stem Cells, JAK/STAT signaling, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors
Bioactivity
MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg) .
Smiles
FC=1C=CC(=CC1)C2=CN=C3NC=C(C=4N=C(N=CC4)NC5CC5)C3=C2
Molecular Formula
C20H16FN5
Molecular Weight
345.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-cyclopropyl-4-[5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
CAS Number2099014-23-8
PubChem CID129206886
IUPAC NameN-cyclopropyl-4-[5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
Molecular FormulaC20H16FN5
Molecular Weight345.4
XLogP3.9
Topological Polar Surface Area66.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity479
SMILES
C1CC1NC2=NC=CC(=N2)C3=CNC4=C3C=C(C=N4)C5=CC=C(C=C5)F
InChI
InChI=1S/C20H16FN5/c21-14-3-1-12(2-4-14)13-9-16-17(11-24-19(16)23-10-13)18-7-8-22-20(26-18)25-15-5-6-15/h1-4,7-11,15H,5-6H2,(H,23,24)(H,22,25,26)
InChIKey
IWEFQYFFHNADPN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-cyclopropyl-4-[5-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine
CAS: 2099014-23-8
CID: 129206886
Formula: C20H16FN5
MW: 345.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.4
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass345.13897369
Monoisotopic Mass345.13897369
Topological Polar Surface Area66.5 Ų
Heavy Atom Count26
Formal Charge0
Complexity479
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-161618-01MJ04

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