GR-73632

CAT: 0804-HY-P1192-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-P1192-01Size:1 mg

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Description

GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist[1]. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals[2].

CAS Number

133156-06-6

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/gr-73632.html

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic)

Smiles

NCCCCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N([C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)C)=O)=O)=O)=O

Molecular Formula

C40H59N7O6S

Molecular Weight

766.00

References & Citations

[1]Sakurada C, et al. Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides. 1999;20 (2) :301-4.|[2]Costantini VJ, et al. The NK1 receptor antagonist aprepitant attenuates NK1 agonist-induced scratching behaviour in the gerbil after intra-dermal, topical or oral administration. Exp Dermatol. 2015 Apr;24 (4) :312-4.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

NK1R

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