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Anti-Ms CD106 PE

CAT: 0270-1P-742-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-1P-742-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity.
Certification
RUO
Reactivity
Mouse
Immunogen
Murine preadipose cell line PA6
Target Antigen
CD106
Clone
429 (MVCAM.A)
Applications
FC (QC tested)
Concentration
0.5 mg/mL
Format
PE
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ: Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. J Immunol. 2012 Sep 1;189 (5) :2488-501., URL: https://www.ncbi.nlm.nih.gov/pubmed/22851707, *Dunzendorfer S, Lee HK, Soldau K, Tobias PS: Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS responses. FASEB J. 2004 Jul;18 (10) :1117-9. Epub 2004 May 7., URL: http://www.ncbi.nlm.nih.gov/pubmed/15132988 , *Sacher T, Knolle P, Nichterlein T, Arnold B, Hämmerling GJ, Limmer A: CpG-ODN-induced inflammation is sufficient to cause T-cell-mediated autoaggression against hepatocytes. Eur J Immunol. 2002 Dec;32 (12) :3628-37., URL: https://www.ncbi.nlm.nih.gov/pubmed/12516551
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The rat monoclonal antibody 429 (also known as MVCAM.A) recognizes an extracellular epitope of murine CD106, a 100-110 kDa type I membrane protein of the immunoglobulin superfamily, a crucial mediator of leukocyte adhesion, and a costimulation molecule.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Isotype
Rat IgG2a kappa

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