Anti-Ms CD105 PE

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Anti-Ms CD105 PE

CAT:

270-1P-714-C100

Size:

0.1 mg

Price:

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For price, please contact [email protected].

Anti-Ms CD105 PE

Background: CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Specifications: The rat monoclonal antibody MJ7/18 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow.
Certification: RUO
Host: Rat
Species Reactivity: Mouse
Immunogen: Inflamed mouse skin
Target Antigen: CD105
Isotype: IgG2a κ
Clone: MJ7/18
Applications: Flow cytometry: Recommended dilution: 1-5 μg/mL.
Validated Applications: FC
Concentration: 0.5 mg/mL
Format: PE
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Ge AZ, Butcher EC: Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand. Gene. 1994 Jan 28138(1-2):201-6., URL: https://pubmed.ncbi.nlm.nih.gov/8125301/,*Herouet C, Cottin M, LeClaire J, Enk A, Rousset F: Contact sensitizers specifically increase MHC class II expression on murine immature dendritic cells. In Vitr Mol Toxicol. 2000 Summer13(2):113-23., URL: http://www.ncbi.nlm.nih.gov/pubmed/11031322 ,*Dassler K, Roohi F, Lohrke J, Ide A, Remmele S, Hütter J, Pietsch H, Pison U, Schütz G: Current limitations of molecular magnetic resonance imaging for tumors as evaluated with high-relaxivity CD105-specific iron oxide nanoparticles. Invest Radiol. 2012 Jul47(7):383-91, URL: http://www.ncbi.nlm.nih.gov/pubmed/22659596 ,*Rosu-Myles M, She YM, Fair J, Muradia G, Mehic J, Menendez P, Prasad SS, Cyr TD: Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells. PLoS One. 20127(6):e38954. doi: 10.1371/journal.pone.0038954., URL: https://pubmed.ncbi.nlm.nih.gov/22719999/,*Cho SK, Bourdeau A, Letarte M, Zú241iga-Pflücker JC: Expression and function of CD105 during the onset of hematopoiesis from Flk1(+) precursors. Blood. 2001 Dec 1598(13):3635-42., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=cho+sk+bourdeau+a ,*Warrington K, Hillarby MC, Li C, Letarte M, Kumar S: Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells. Anticancer Res. 2005 May-Jun25(3B):1851-64., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=warrington+k+hillarby+mc ,*Fonsatti E, Nicolay HJ, Altomonte M, Covre A, Maio M: Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours. Cardiovasc Res. 2010 Apr 186(1):12-9. doi: 10.1093/cvr/cvp332., URL: http://www.ncbi.nlm.nih.gov/pubmed/19812043 ,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

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