Anti-Lactoferrin Purified

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MBS1800860-01	Anti-Lactoferrin Purified
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MBS5308355-01	Purified native Lactoferrin protein
MBS5308355-02	Purified native Lactoferrin protein
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LF-PA0109	anti-Lactoferrin
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CAT:

270-11-128-C100

Size:

0.1 mg

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Anti-Lactoferrin Purified

Background: Lactoferrin is an iron-binding glycoprotein of the transferrin family, which is released to most biological fluids, with particularly high levels in milk. It has anti-inflammatory (e.g. sequestering of lipopolysaccharides), anti-microbial (e.g. blocking of viral attachment to the target cell), and immunomodulatory properties and can prevent infections in young children. Lactoferrin is considered to bridge the innate and adaptive immune responses. It also participates in iron homeostasis, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Besides biological fluids it is also found in the secondary granules of neutrophils.
Specifications: The mouse monoclonal antibody LF5-1D2 recognizes lactoferrin, an iron-binding secreted glycoprotein of about 90 kDa, which has anti-inflammatory, immunomodulatory and anti-microbial properties.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: human lactoferrin
Target Antigen: Lactoferrin
Isotype: IgG1
Clone: LF5-1D2
Applications: Flow cytometry: Recommended dilution: 1-4 µg/mL. Intracellular staining.
Validated Applications: FC, ELISA
Concentration: 1 mg/mL
Format: Purified
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Zwirzitz A, Reiter M, Skrabana R, Ohradanova-Repic A, Majdic O, Gutekova M, Cehlar O, Petrovčíková E, Kutejova E, Stanek G, Stockinger H, Leksa V: Lactoferrin is a natural inhibitor of plasminogen activation. J Biol Chem 2018 293(22) 8600-8613, URL: https://pubmed.ncbi.nlm.nih.gov/29669808/,
Other References: *Turin CG, Zea-Vera A, Pezo A, Cruz K, Zegarra J, Bellomo S, Cam L, Llanos R, Casta241eda A, Tucto L, Ochoa TJ NEOLACTO Research Group: Lactoferrin for prevention of neonatal sepsis. Biometals. 2014 Oct27(5):1007-16. doi: 10.1007/s10534-014-9754-3., URL: https://pubmed.ncbi.nlm.nih.gov/24935001/,*Siqueiros-Cendón T, Arévalo-Gallegos S, Iglesias-Figueroa BF, García-Montoya IA, Salazar-Martínez J, Rascón-Cruz Q: Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014 May35(5):557-66., URL: https://pubmed.ncbi.nlm.nih.gov/24786230/,
Storage Conditions: Store at 2-8°C. Do not freeze.

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