Anti-Lactoferrin PE

• Description:

  Lactoferrin is an iron-binding glycoprotein of the transferrin family, which is released to most biological fluids, with particularly high levels in milk. It has anti-inflammatory (e.g. sequestering of lipopolysaccharides), anti-microbial (e.g. blocking of viral attachment to the target cell), and immunomodulatory properties and can prevent infections in young children. Lactoferrin is considered to bridge the innate and adaptive immune responses. It also participates in iron homeostasis, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Besides biological fluids it is also found in the secondary granules of neutrophils.

• Certification:

  RUO

• Reactivity:

  Human

• Immunogen:

  Human lactoferrin

• Target Antigen:

  Lactoferrin

• Clone:

  LF5-1D2

• Applications:

  FC-IC (QC tested)

• Format:

  PE

• Buffer:

  Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• References & Citations:

  *Zwirzitz A, Reiter M, Skrabana R, Ohradanova-Repic A, Majdic O, Gutekova M, Cehlar O, Petrovčíková E, Kutejova E, Stanek G, Stockinger H, Leksa V: Lactoferrin is a natural inhibitor of plasminogen activation. J Biol Chem 2018; 293 (22) 8600-8613, URL: https://pubmed.ncbi.nlm.nih.gov/29669808/

• Other References:

  *Turin CG, Zea-Vera A, Pezo A, Cruz K, Zegarra J, Bellomo S, Cam L, Llanos R, Castañ eda A, Tucto L, Ochoa TJ; NEOLACTO Research Group: Lactoferrin for prevention of neonatal sepsis. Biometals. 2014 Oct;27 (5) :1007-16. doi: 10.1007/s10534-014-9754-3., URL: https://pubmed.ncbi.nlm.nih.gov/24935001/, *Siqueiros-Cendón T, Arévalo-Gallegos S, Iglesias-Figueroa BF, García-Montoya IA, Salazar-Martínez J, Rascón-Cruz Q: Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014 May;35 (5) :557-66., URL: https://pubmed.ncbi.nlm.nih.gov/24786230/

• Storage Conditions:

  Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

• Specificity:

  The mouse monoclonal antibody LF5-1D2 recognizes lactoferrin, an iron-binding secreted glycoprotein of about 90 kDa, which has anti-inflammatory, immunomodulatory and anti-microbial properties.

• Applications Notes:

  6

• Isotype:

  Mouse IgG1