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Anti-Lactoferrin PE

CAT: 0270-1P-128-T100Size: 100 TestsDry Ice: NoHazardous: No
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CAT#:0270-1P-128-T100Size:100 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lactoferrin is an iron-binding glycoprotein of the transferrin family, which is released to most biological fluids, with particularly high levels in milk. It has anti-inflammatory (e.g. sequestering of lipopolysaccharides), anti-microbial (e.g. blocking of viral attachment to the target cell), and immunomodulatory properties and can prevent infections in young children. Lactoferrin is considered to bridge the innate and adaptive immune responses. It also participates in iron homeostasis, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Besides biological fluids it is also found in the secondary granules of neutrophils.
Certification
RUO
Reactivity
Human
Immunogen
Human lactoferrin
Target Antigen
Lactoferrin
Clone
LF5-1D2
Applications
FC-IC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Zwirzitz A, Reiter M, Skrabana R, Ohradanova-Repic A, Majdic O, Gutekova M, Cehlar O, Petrovčíková E, Kutejova E, Stanek G, Stockinger H, Leksa V: Lactoferrin is a natural inhibitor of plasminogen activation. J Biol Chem 2018; 293 (22) 8600-8613, URL: https://pubmed.ncbi.nlm.nih.gov/29669808/
Other References
*Turin CG, Zea-Vera A, Pezo A, Cruz K, Zegarra J, Bellomo S, Cam L, Llanos R, Castañ eda A, Tucto L, Ochoa TJ; NEOLACTO Research Group: Lactoferrin for prevention of neonatal sepsis. Biometals. 2014 Oct;27 (5) :1007-16. doi: 10.1007/s10534-014-9754-3., URL: https://pubmed.ncbi.nlm.nih.gov/24935001/, *Siqueiros-Cendón T, Arévalo-Gallegos S, Iglesias-Figueroa BF, García-Montoya IA, Salazar-Martínez J, Rascón-Cruz Q: Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014 May;35 (5) :557-66., URL: https://pubmed.ncbi.nlm.nih.gov/24786230/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody LF5-1D2 recognizes lactoferrin, an iron-binding secreted glycoprotein of about 90 kDa, which has anti-inflammatory, immunomodulatory and anti-microbial properties.
Applications Notes
6
Isotype
Mouse IgG1

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