BAY-27-9955

CAT: 0804-HY-19374-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-19374-01Size:5 mg

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Description

BAY-27-9955 is an orally active non-peptide glucagon receptor antagonist. Bay 27-9955 competitively blocks the interaction of glucagon with the human glucagonreceptor at an IC50 value of 110 nM. BAY-27-9955 can be used for the study of type 2 diabetes[1].

CAS Number

202855-56-9

UNSPSC

12352005

Target

GCGR

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bay-27-9955.html

Smiles

OC(C)C1=C(C(C)C)C=C(C(C)C)C(CCC)=C1C2=CC=C(F)C=C2

Molecular Formula

C23H31FO

Molecular Weight

342.49

References & Citations

[1]K F Petersen, et al. Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Diabetologia. 2001 Nov;44 (11) :2018-24.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Chemical Information

Bay 27-9955

CAS Number	202855-56-9
PubChem CID	5311277
IUPAC Name	1-[2-(4-fluorophenyl)-4,6-di(propan-2-yl)-3-propylphenyl]ethanol
Molecular Formula	C23H31FO
Molecular Weight	342.5
XLogP	6.8
Topological Polar Surface Area	20.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Heavy Atom Count	25
Formal Charge	0
Complexity	386

SMILES

CCCC1=C(C(=C(C=C1C(C)C)C(C)C)C(C)O)C2=CC=C(C=C2)F

InChI

InChI=1S/C23H31FO/c1-7-8-19-20(14(2)3)13-21(15(4)5)22(16(6)25)23(19)17-9-11-18(24)12-10-17/h9-16,25H,7-8H2,1-6H3

InChIKey

VDTWKXAPIQBOMO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 202855-56-9

CID: 5311277

Formula: C23H31FO

MW: 342.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	342.5
XLogP3	6.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Exact Mass	342.23589377
Monoisotopic Mass	342.23589377
Topological Polar Surface Area	20.2 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	386
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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