EAAT2 activator 2

• Description :

  EAAT2 activator 2 (Compound 4 (SF-2) ) is a brain-penetrant excitatory amino acid transporter 2 (EAAT2) modulator (Ki=28.7 nM) . EAAT2 activator 2 enhances EAAT2-mediated glutamate uptake, improving synaptic glutamate clearance. EAAT2 activator 2 is promising for research of neurodegenerative diseases (e.g., ALS, Alzheimer’s disease) [1].

• UNSPSC :

  12352005

• Target :

  EAAT

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Neurological Disease

• Smiles :

  FCCOC1=CC=C(C=C1)NC(C(N2CCN(CC2)C3=CC=CC=C3)=O)=O

• Molecular Formula :

  C20H22FN3O3

• Molecular Weight :

  371.41

• References & Citations :

  [1]Song P, et al. Development of radiolabeling 2-oxo-2- (4-phenylpiperazin-1-yl) acetamide derivatives as potential molecular probes for excitatory amino acid transporter 2. Eur J Med Chem. 2025 Jul 16;298:117981.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EAAT2