EAAT2 activator 2

• Description:

  EAAT2 activator 2 (Compound 4 (SF-2) ) is a brain-penetrant excitatory amino acid transporter 2 (EAAT2) modulator (Ki=28.7 nM) . EAAT2 activator 2 enhances EAAT2-mediated glutamate uptake, improving synaptic glutamate clearance. EAAT2 activator 2 is promising for research of neurodegenerative diseases (e.g., ALS, Alzheimer’s disease) [1].

• UNSPSC:

  12352005

• Target:

  EAAT

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Neurological Disease

• Smiles:

  FCCOC1=CC=C (C=C1) NC (C (N2CCN (CC2) C3=CC=CC=C3) =O) =O

• Molecular Formula:

  C20H22FN3O3

• Molecular Weight:

  371.41

• References & Citations:

  [1]Song P, et al. Development of radiolabeling 2-oxo-2- (4-phenylpiperazin-1-yl) acetamide derivatives as potential molecular probes for excitatory amino acid transporter 2. Eur J Med Chem. 2025 Jul 16;298:117981.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  EAAT2