PD-L1-IN-1

PD-L1-IN-1

• CAS Number: 2767424-13-3
• UNSPSC Description: PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-l1-in-1.html
• Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: CC(NCCNC1=NC(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)=NC=N1)=O
• Molecular Weight: 377.44
• References & Citations: [1]Russomanno P, et al. Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors. J Med Chem. 2021;64(21):16020-16045.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported