BI-6015

• Description :

  BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BI6015 represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  Orphan Nuclear Receptor; Orphan Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/bi-6015.html

• Purity :

  99.90

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=S(N1C2=CC=CC=C2N=C1C)(C3=CC([N+]([O-])=O)=CC=C3C)=O

• Molecular Formula :

  C15H13N3O4S

• Molecular Weight :

  331.35

• Precautions :

  H315, H319

• References & Citations :

  [1]Kiselyuk A, et, al. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19 (7) :806-18.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [93987-29-2]