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PF-04279405

CAT: 0804-HY-136631Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-136631Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-04279405 is a potent and full-acting glucokinase (GK) agonist (EC50=23 nM) . Glucokinase (GK) is an enzyme responsible for the conversion of glucose to glucose-6-phosphate and plays a key role in maintaining blood glucose homeostasis. PF-04279405 can be used in the research of type 2 diabetes[1].
CAS Number
955881-01-3
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Glucokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pf-04279405.html
Smiles
O=C(C1=CC(OC2=CC=C(C(N3CCC3)=O)C(F)=C2)=C4CC(C)(C)OC4=C1)NC5=NN(C)C=C5
Molecular Formula
C25H25FN4O4
Molecular Weight
464.49
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Pettersen, et al. The relationship of glucokinase activator–induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies. Toxicologic Pathology 42.4 (2014) : 696-708.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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