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BL-B01D1

CAT: 0804-HY-164702-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-164702-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BL-B01D1 is a bispecific ADC, which targets EGFR and HER3 through bispecific antibody Izalontamab , and exhibits cytotoxicity against various cancer cells via inhibition of DNA replication and DNA synthesis by its ADC toxin ED04 (HY-153891).
UNSPSC
12352211
Target
Antibody-Drug Conjugates (ADCs) ; EGFR
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bl-b01d1.html
Purity
99.53
Smiles
[BL-B01D1]
Molecular Weight
205830.00
References & Citations
[1]Ma Y, et al., BL-B01D1, a first-in-class EGFR-HER3 bispecific antibody-drug conjugate, in patients with locally advanced or metastatic solid tumours: a first-in-human, open-label, multicentre, phase 1 study. Lancet Oncol. 2024 Jul;25 (7) :901-911.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light
Scientific Category
Reference compound1
Clinical Information
Phase 3

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