BL-B01D1
CAT:
804-HY-164702-02
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BL-B01D1
- UNSPSC Description: BL-B01D1 is a bispecific ADC, which targets EGFR and HER3 through bispecific antibody Izalontamab (HY-P99676), and exhibits cytotoxicity against various cancer cells via inhibition of DNA replication and DNA synthesis by its ADC toxin ED04 (HY-153891)[1].
- Target Antigen: Antibody-Drug Conjugates (ADCs); EGFR
- Type: Reference compound
- Related Pathways: Antibody-drug Conjugate/ADC Related;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/bl-b01d1.html
- Smiles: [BL-B01D1]
- References & Citations: [1]Ma Y, et al., BL-B01D1, a first-in-class EGFR-HER3 bispecific antibody-drug conjugate, in patients with locally advanced or metastatic solid tumours: a first-in-human, open-label, multicentre, phase 1 study. Lancet Oncol. 2024 Jul;25(7):901-911.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported