BL-1249

CAT: 0804-HY-108596-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108596-01Size:1 mg
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Description
BL-1249 is a nonsteroidal anti-inflammatory agent (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM) [1][2].
CAS Number
[18200-13-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bl-1249.html
Purity
99.81
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(NC2=C3CCCCC3=CC=C2)=CC=CC=C1C4=NN=NN4
Molecular Formula
C17H17N5
Molecular Weight
291.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Tertyshnikova S, et al. BL-1249 [ (5,6,7,8-tetrahydro-naphthalen-1-yl) -[2- (1H-tetrazol-5-yl) -phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties. J Pharmacol Exp Ther. 2005 Apr;313 (1) :250-9.|[2]Pope L, et al. Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels. ACS Chem Neurosci. 2018 Dec 19;9 (12) :3153-3165.|[3]Iwaki Y, et al. Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249. Bioorg Med Chem Lett. 2019 Jul 1;29 (13) :1601-1604.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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