BL-1005

• Description:

  BL-1005 (BS2463), thiophen-2-yl pyrimidine (TTP), is a potent paralytic of Schistosoma mansoni with an EC50 of 37 nM. BL-1005 shows low cytotoxicity for HEK293, HeLa and HepG2 cell with CC50 >20 μM. BL-1005 can induce paralysis in both adult and juvenile S. mansoni. BL-1005 can be used for the research of infection[1].

• Product Name Alternative:

  BS2463

• UNSPSC:

  12352005

• Target:

  Parasite

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  FC(C=C(C=C1F)N)=C1C(C(Cl)=NC(C2=CC=CS2)=N3)=C3NCC4(C)COC4

• Molecular Formula:

  C19H17ClF2N4OS

• Molecular Weight:

  422.88

• References & Citations:

  [1]Francisco KR, et al. Structure-Activity Relationship and Target Investigation of Thiophen-2-yl-Pyrimidines against Schistosoma species. bioRxiv [Preprint]. 2025 Oct 8:2025.10.07.681061.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported