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(S) -AZD 6482

CAT: 0804-HY-118236Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118236Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -AZD6482 ((S) -KIN-193) is a highly effective and selective ATP-competitive inhibitor of PI3Kβ, exhibiting an IC (50) of 0.01 μM, and it can reduce insulin-induced glucose uptake by human adipocytes in vitro with an IC (50) of 4.4 μM.
CAS Number
1173900-37-2
Product Name Alternative
(S) -KIN-193
UNSPSC
12352005
Hazard Statement
H302-H315-H320-H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/s-azd-6482.html
Smiles
O=C(C1=CC=CC=C1N[C@@H](C)C2=CC(C)=CN3C2=NC(N4CCOCC4)=CC3=O)O
Molecular Formula
C22H24N4O4
Molecular Weight
408.45
Precautions
P261-P280-P302+P352
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

AZD6482 (S-isomer)
CAS Number1173900-37-2
PubChem CID57789333
IUPAC Name2-[[(1S)-1-(7-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid
Molecular FormulaC22H24N4O4
Molecular Weight408.4
XLogP2
Topological Polar Surface Area94.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity838
SMILES
CC1=CN2C(=O)C=C(N=C2C(=C1)[C@H](C)NC3=CC=CC=C3C(=O)O)N4CCOCC4
InChI
InChI=1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m0/s1
InChIKey
IRTDIKMSKMREGO-HNNXBMFYSA-N
Chemical Structure
2D Structure
2D structure of AZD6482 (S-isomer)
CAS: 1173900-37-2
CID: 57789333
Formula: C22H24N4O4
MW: 408.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight408.4
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass408.17975526
Monoisotopic Mass408.17975526
Topological Polar Surface Area94.5 Ų
Heavy Atom Count30
Formal Charge0
Complexity838
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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