AZD 6482

• Description:

  AZD 6482 (KIN-193) is a potent and selective p110β inhibitor with an IC50 of 0.69 nM.

• Product Name Alternative:

  KIN-193

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H320, H335

• Target:

  Autophagy; PI3K

• Type:

  Reference compound

• Related Pathways:

  Autophagy; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/AZD-6482.html

• Concentration:

  10mM

• Purity:

  99.93

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1N2C(C([C@H](NC3=CC=CC=C3C(O)=O)C)=CC(C)=C2)=NC(N4CCOCC4)=C1

• Molecular Formula:

  C22H24N4O4

• Molecular Weight:

  408.45

• Precautions:

  H302, H315, H320, H335

• References & Citations:

  [1]Ni J, et al. Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2012 May;2 (5) :425-33.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  PI3KC2β; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34

• CAS Number:

  [1173900-33-8]