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Protriptyline (hydrochloride) (Standard)

CAT: 0804-HY-B0949R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0949R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protriptyline hydrochloride (Standard) is the analytical standard of Protriptyline hydrochloride. This product is intended for research and analytical applications. Protriptyline hydrochloride is a potent tricyclic antidepressant (TCA). Protriptyline hydrochloride inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline hydrochloride can be used for the study of depression and Alzheimers disease[1][2][3].
CAS Number
1225-55-4
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Reference Standards
Type
Reference Standards
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/protriptyline-hydrochloride-standard.html
Smiles
CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.[H]Cl
Molecular Formula
C19H22ClN
Molecular Weight
299.84
References & Citations
[1]Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9 (8) :e105196.|[2]Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35 (5) :429-34.|[3]Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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