Protriptyline-d3

• Description :

  Protriptyline-d3 is deuterium labeled Protriptyline (HY-B0949) . Protriptyline is a potent tricyclic antidepressant (TCA) . Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease[1][2][3].

• UNSPSC :

  12352005

• Target :

  Amyloid-β; Cholinesterase (ChE) ; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Neuronal Signaling; Others

• Field of Research :

  Neurological Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]C([2H])([2H])NCCCC1C2=C(C=CC=C2)C=CC3=C1C=CC=C3

• Molecular Formula :

  C19H18D3N

• Molecular Weight :

  266.40

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9 (8) :e105196.|[3]Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35 (5) :429-34.|[4]Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [136765-50-9]