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Protriptyline-d3

CAT: 0804-HY-B0949AS-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0949AS-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protriptyline-d3 is deuterium labeled Protriptyline. Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease[1][2][3].
CAS Number
136765-50-9
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])NCCCC1C2=C(C=CC=C2)C=CC3=C1C=CC=C3
Molecular Formula
C19H18D3N
Molecular Weight
266.40
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9 (8) :e105196.|[3]Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35 (5) :429-34.|[4]Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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